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Chris,
I had the same treatments and had the same symptoms as your husband over the following years. After assuming it was GERD and getting no relief from antacids over a period of a about 5 years I had one night when it felt like I had a flaming spear thrown into my chest. It turned out to be gall bladder stones that had eventually blocked my common bile duct. This blocks both the pancreas and the liver so it is life threatening in a week or so but your urine turns dark brown to black so you really know something is wrong once you finally get a complete blockage. Something to consider.