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The history you provide appears to be rare if not unique, perhaps, explaining why no one on this site has commented thus far.
A biopsy may give you some of the information you need to make a good decision for yourself.
Best wishes Don O.
Thanks for the reply. My GP has suggested a 4K, MRI or enzyme test prior to an actual biopsy due to the uniqueness of my situation so will probably initially go that route. Any comments from the forum as to experiences with any of those 3 diagnostic tools? Thx
Following a PSA reading of 5.8 and a range of of inconclusive tests, including a MRI, I had a transperineal biopsy in 2013. My urology consultant thought that I would end up having a biopsy at some stage and it might be as well to have one sooner rather than later. Quite glad really as the biopsy found extensive cancer which was treated by surgery, radiotherapy and hormone therapy in the following 3 years. Some unavoidable side effects but generally I consider myself fortunate and continue to enjoy life. These decisions are always difficult. Best of luck with yours.
Just to conclude this post (as it applies to me anyway), I found a very caring, prostate cancer surviving, minimally invasive treatment thinking doctor. He suggested a 3T MRI w/wo contrast prior to a biopsy. Being a long distance away (to avoid 2 trips), the MRI scheduled one afternoon, biopsy the next morning. The morning after the MRI, we met with the Urologist and he told us the radiologist and himself could find absolutely no signs of cancer lesions. What he did find was a prostate 6x larger than normal! With no symptoms, no cancer history in family, etc we skipped the biopsy and he indicated that he would not be concerned (absent any future symptoms) until a PSA much higher. So, please find a doctor who wants the real story before performing any type of biopsy.