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Don I had a read of your blog re the various therapies we discussed previously. For whatever reason, your treatment modalities as related, are reserved for advanced metastatic disease here in Australia. As you say, your recurrence appears to be localised, thus I am somewhat puzzled why your clinicians chose to bring out the big gun (abby/enzo), unless of course at your request/cost. Please understand that clinical approaches twixt your country and mine don't always coalesce.
As I said previously, in my view a localised focal therapy is very appropriate in your/my circumstance. I say this because irrespective of the therapy chosen, delay to progression will occur particularly given the longevity of our journeys thus far. Destruction of the tumor DNA (Gleason grading of course not withstanding) will provide an ideal opportunity to put the big guns back in the holster, for when they are really needed, when progression outside the prostate capsule takes place, assuming of course that it ever does.
In about three and a half years time, assuming my PSA velocity continues at the same rate, I too will be confronted with the same dilemma as you Don. At present I am leaning towards LD brachy. My PSA is rising by 0.16 every six months. My nada is 2.05. Current PSA is 0.81.So I have done well considering my GL was 7 (4+3) way back in in early 2008 when I was treated with EBRT.
No doubt a biopsy will be required prior to a Rx choice decision. Who know's if the tumor is Gl 5 or 6, watchful waiting may be my choice. My lifespan is only about another 10 years at best, due to co-morbidity. I am 70 now. So allowing say another 3 years to biochemical recurrence, combined with a minimally effective local focal therapy, say another 3 years, the remaining 4 years are of little consequence to me, assuming I will probably drop dead of a cardiac event anyway. I guess my Rx choice is all about buying time whilst acknowledging that time is finite. I guess it just depends on your perspective Don. To me quality of life is paramount. When I no longer have that, my journey will be completed and I am very comfortable with that.
Sorry to waffle on Don. Few answers I know, but at least I have given you my perspective of a journey we are both sharing.
Xtandi was one of several options I considered following my recurrence.
My Sept.10,2018 journal entry provides a summary of four other options I considered . My concluding thoughts on one of these, i. e., H D Brachy appear below:
"Of those listed H D Brachy appears most acceptable to me. Is it preferable to plugging away with various forms of ADP? That my friends is the question of the day. It's a crap shoot, always has been, always will be-- this time with far less favorable odds than when I opted for PBRT at the outset. In any event I intend to let the matter percolate for the time being."
I am very much interested in what you decide and how you fare as you proceed. You undoubtedly know how to track my progress.
Best wishes Don O.
Glad to read this back-n-forth. Diagnosed in Oct 2009 at PSA 4.6 Gleason 6 one core 5%, I have been on Active Surveillance since. Slow progression in PSA, few ups and downs (one high of 10.5 in 2013, then quickly back to 5. A year ago 7.6, just today 12.5. Will see what Dr says at appointment in 2 weeks. Hard to believe we lost Terry 6 years ago last week. Best to all.