Prostate Cancer Survivors

 

YANA - YOU ARE NOT ALONE NOW

PROSTATE CANCER SUPPORT SITE

 

 

Return to Website

This forum is for the discussion of anything to do with Prostate Cancer.
There are only four rules:

  • No fundraisers, no commercials (although it is OK to recommend choices of treatment or medical people based on your personal research; invitations to participate in third-party surveys are also acceptable, provided there is no compensation to YANA);
  • No harvesting e-mail addresses for Spam;
  • No insults or flaming - be polite and respectful at all times and understand that there may be a variety of points of view, all of which may have some validity;
  • Opinions are OK, but please provide as much factual evidence as possible for any assertions that you are making

Failure to abide by these simple rules will result in the immediate and permanent suspension of your posting privileges.

Since this is an International Forum, please specify your location in your post.

General Forum
Start a New Topic 
Author
Comment
Dutasteride (5ARI) Resistance?

Is there such a thing as 5ARI resistance - especially for metastatic patients?

From my limited research, it seems metastatic patients who employ ADT3 experience a pronounced dip in PSA to as low as 0.01. But in about 7 months the DHT levels spike up to their original levels. As the DHT levels rise the PSA increases. The DHT levels then stabilize to what they should be without Dutaseride. (Also refer to Avias Trial)

This PSA rise is NOT true CRPC because the PSA rise is due to 5ARI resistance. If the majority of cells are still androgen dependent at this point the PSA should stabilize albeit at a higher level.

The result is that people who employ ADT2 would stabilize at the same PSA level as will patients who employ ADT3 but without the "false" dip to very low levels followed by a PSA spike.

RETURN TO HOME PAGE LINKS