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Re: Avodart affect on biopsy tissue Gleason score ?

Brian I find very interesting the statement that “finasteride may induce some foci of lower grade cancer to resemble higher grade cancer." Really?
About 6 years ago I was diagnosed with a small amount of GS 6 PCa. I decided to go on A.S. with PSA tests every 3 months. My uro supported my A.S. but he seemed more concerned about my PSA velocity which he felt was greater than it should be for the small amount of cancer I seemed to have (2 cores each <5%). He put me on finasteride. It did slow the increase in PSA, but it did not stop it. I took it for about 18 months but stopped because I felt that the finasteride might be masking the "real" PSA level. My next biopsy showed I now appeared to have GS 8 PCa. Are you saying there exists the possibility that my GS 8 cancer might not have been "real" GS 8, but only GS 6 made to "resemble" GS 8?

Re: Avodart affect on biopsy tissue Gleason score ?

Joe, you can find the statement "finasteride may induce some foci of lower grade cancer to resemble higher grade cancer" in the paper:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297839/

The whole paper is long but interesting. For the quote, scroll down to paragraph 3 of the Discussion, where reference 21 is shown.



Re: Avodart affect on biopsy tissue Gleason score ?

Thanks for the replies, who is the individual replying in the original quote I copied?

Re: Avodart affect on biopsy tissue Gleason score ?

Maybe you should take your doctor's advice and get cured while you are young. A good surgeon in combination with your youth should mitigate the side effects: a stitch in time...

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