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Testosterone on which the PCa feeds arises in three places: the testes (Zoladex or equivalent - I presume Suprefact is this - deals with this), the adrenal glands (Casodex supposedly deals with this) and in the PCa cells themselves. The first two types of ADT don't deal with this third source, as I have found. I've been just five weeks on Zytiga (very expensive in the USA I know) with a steroid to counter its supposed side effects and the results have already been dramatic for me. If you can find a way of getting on this, you may find, as I have found, that there are no side effects at all! If you take this route you'll need to stay on the Zoladex or equivalent, though. I suggest if you can get that extra weight off you may find the lethargy goes with it. Again, I've found that, but I confess that muscle wastage is a side effect of ADT, which so far I haven't been able to counter over the sic years I've been on it.
Morton,
I am not in your position yet but I have had the LHRH/Casodex and I know it is not easy to be on. Your oncologist is trying to keep you alive until some better drugs are available and the best way to do that is for you to stay on the LHRH and anything else that they think will help. Zytiga should help and there are a new class of nanoparticles combined with radiation particles that are starting into clinical trials that might be worth trying to get in on.
