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I have read the latest comments regarding Gleason grade progression. The results of the Penney study and Terry's most recent biopsy would indicate that once again with PCa "There Are No Rules". This disease must be as extremely frustrating for researchers and clinicians, as it is for patients.
I would like to comment on having a MRI to find the location of your cancer. While a conventional MRI is not very good at seeing prostate cancer. A multi-modal MRI is very good at finding prostate cancer. Here is a link to a article that says the accuracy of detection cancer with a multi-modal MRI is more than 90%. http://www.umcn.nl/Zorg/Afdelingen/Radiologie/Documents/MRI%20in%20PCa%20PCRI%20Insights%20short%20(2).pdf
