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You refer to "....a rapidly rising PSA....." but that is a little vague. I am pretty certain, from your previous posts that you are not talking about microscopic changes in ultra-sensitive tests which are sometimes referred to in these terms - for example from 0.012 to 0.013 to 0.015 etc But I'm guessing in your case there is a different set of figures.
You also say that these PSA result "....is evidence that it (Lupron)) is not working...." That indeed is the commonly held view, but a recent video by Dr Chrles "Snuffy" Myers suggests that may not always be the case. I have tried to interpret the technicalities of his video in my latest E-Letter#14and you might find that of interest - there is also a link to the video in the E-Letter.
Having said all that I decided to withdraw all treatment late last year - I was on Zoladex and Casodex - because my PSA started to rise and also because I reverted to my original distrust of the value of PSA tests for measuring dangerous advances of the disease - or should I say for the variant I have been diagnosed with. By chance that was before I saw the Myers' video. You can read my reasoning (such as it is) at TERRY HERBERT .
Although I wanted to go a full year with no medication to see if there would be any correlation between a signifcant change in PSA and evidence of progression of the disease, my oncologist was a little nervous of that, so we compromised and we'll check it out in June. Stand by for that report in due course!
Hope this helps some - it is a complex business.
Terry in Australia
