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Remember that biopsies are not risk free. You have something like a 1 in 30 chance of getting a life threatening infection. As a 41 year old caucasian your chance of dying from prostate cancer in the next four years is a lot less than 1 in a 1000. Given that you've already had a cryoscopy, DRE and TRUS that all came back normal I just don't see why you would worry about PC.
Tom, I just had a radical prostatectomy last week so my thoughts may be some what different than most and is mostly based on hindsight after just getting my pathology report.
To me the answer to biopsy or not depends on if you are the type of person that can live with uncertainty or one that needs a difinitive answer. I've had two biopsies, after the first I elected to watch and wait, which I did for one year, but not without some worry some days. The second biopsy was slightly worse so I elected surgery.
My pathology report indicated a small tumor less than 2 cc out of 34. I'm guessing this had been there for more than 10 years.
So in retrospect as I sit here dripping, not only should I have not had the surgery but I think I would have been better off had I not had the biopsy!
I believe this is the same logic the American Society of Oncologists used when they recommended to do away with routine PSA screening for men over 50. It does more harm than good, leads to worry and over treatment.