This forum is for the discussion of anything to do with Prostate Cancer. There are only four rules:
No fundraisers, no commercials (although it is OK to recommend choices of treatment or medical people based on your personal research; invitations to participate in third-party surveys are also acceptable, provided there is no compensation to YANA);
No harvesting e-mail addresses for Spam;
No insults or flaming - be polite and respectful at all times and understand that there may be a variety of points of view, all of which may have some validity;
Opinions are OK, but please provide as much factual evidence as possible for any assertions that you are making
Failure to abide by these simple rules will result in the immediate and permanent suspension of your posting privileges.
Since this is an International Forum, please specify your location in your post.
Re: Testosterone ratio to Estrogen and risk of prostate cancer.
Maybe I can redeem myself with this information. In the following site,
testosteronewisdom.com, I see that, assuming a normal level of Testosterone of 300-1000 ng/dl, the level of estradiol, a marker for estrogen, should be between 14-54 pg/ml. I understand that DHEA converts to testosterone as well as estrogen. I wonder if this conversion provides the correct ratio.
Re: Testosterone ratio to Estrogen and risk of prostate cancer.
Sorry Jack, I do not have the time to read right through the site to find the figures you mention, but doubt very much, looking at other aspects of the site that there would be any good data to show a link between T/E levels and PCa.
But even if it was, is the ratio 14/300 or 14/1000 or 54/300 or 54/1000?Those are two wide ranges to draw firm conclusions in my opinion.
I see the author of the site is described as
Nelson Vergel is a 25+ year long term HIV survivor. Aided by his chemical engineering degree and obsession for scientific data, he adds his own personal experience as he demystifies many health myths. For the last 20 years, his trial-and-error experience to improve his quality of life has paved the way for others to learn from his knowledge.
Personal trial-and-error experiments, while interesting, are rarely sound bases for making sound decisions - especially when these experiments are the basis for selling anything - like a book or.....
Re: Testosterone ratio to Estrogen and risk of prostate cancer.
This is from a blog on the site,wwwtestosteronewisdom.com. Elsewhere there is a mention of using T replacement with caution in cases of Pca.
The normal production ratio of testosterone to estrogen is approximately 100:1. The normal ratio of testosterone to estrogen in the circulation is approximately 300:1. Estrogen (measured as estradiol) should be kept at 30 picograms per milliliter (pg/mL) or lower. As men grow older or as they gain a lot of fat mass, their estrogen blood levels increase, even to levels higher than that of postmenopausal women.
This is a site which speaks of a small study which suggests that use of estradiol reduces testosterone with fewer risks for osteoporosis and heart problems and, while enlarged breasts still occur, men had fewer complaints regarding hot flashes. That brings to mind the videos I've seen of Dr. Meyers. Maybe I got it all wrong, but it seems he promotes the use of estradiol and Testosterone therapy at the same time. I hope someone can clear this up for me. My primary doctor practices integrative medicine and we kicked around the idea of T. replacement. My urologist said my testosterone will go up now that I'm 'on vacation' from my injections. I decided to take DHEA, which converts to testosterone and estrogen, and my primary doctor has no problem with that.
Aloha,
Have you been following Ralph Valle comments? I asked Mike where these articles were located and he gave me
http://www.ncbi.nlm.nih.gov/sites/entrez
Using "Testosterone Prostate Cancer" brings up many abstracts.
Here are 3 that I found in the first few pages;
Future Oncol. 2009 Sep;5(7):1005-13.
Association between serum sex hormone levels and prostate cancer: effect of prostate cancer on serum testosterone levels.
ScientificWorldJournal. 2009 Jul 27;9:685-90.
Rapidly shifting concepts regarding androgens and prostate cancer.
J Steroid Biochem Mol Biol. 2009 Mar;114(1-2):96-105. Epub 2009 Jan 30.
Testosterone deficiency syndrome: treatment and cancer risk.
Joe
