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Just to balance the debate, I'd like to say that I've had no problems at all with 12 weekly shots of Zoladex (Lupron) - I've been 4 years on the stuff having had EBRT also. Clearly, some guys have had problems with big doses, though the 4- or 12-week implants issue the drug at much the same pace I believe, whether you have the smaller or bigger doses.
To me. given that it's a big needle and sometimes the nurse misses the sub-cutaneous fat (where it is supposed to go) and penetrates muscle (which you can feel grinding/squelching as the needle goes through) it is quite a good thing to put off the discomfort of those misses to 12-weekly rather than four-weekly intervals! This is an argument for maintaining some fat on your body and not getting too damned slim!
for what it's worth I was on Zoladex for 15 months with the 12 weekly shot, the injection itself never ever gave trouble, the side effects were unpleasant to say the least, it has been all over now for 3 months and I am in remission,so, was it worth it? you betcha!
Just a minor point: You mentioned shots given by the nurse. I went through a series of 16 injections of Firmagon (Degarelix), each time given by my doctor, rather than the nurse. At first he pushed the material through the needle too fast and it would be painful, so he caught on that it should be pushed in slowly. This had no effect on the pain, the hardening, (induration) at the injection site that would develop later.