This forum is for the discussion of anything to do with Prostate Cancer. There are only four rules:
No fundraisers, no commercials (although it is OK to recommend choices of treatment or medical people based on your personal research; invitations to participate in third-party surveys are also acceptable, provided there is no compensation to YANA);
No harvesting e-mail addresses for Spam;
No insults or flaming - be polite and respectful at all times and understand that there may be a variety of points of view, all of which may have some validity;
Opinions are OK, but please provide as much factual evidence as possible for any assertions that you are making
Failure to abide by these simple rules will result in the immediate and permanent suspension of your posting privileges.
Since this is an International Forum, please specify your location in your post.
Phase II drugs now using saracatinib (Astrazeneca mfg.)+ chloroquine
Chloroquine is a malaria drug, approved by FDA already and in another study it is found that Sprycel (Dasatinib) + Chloroquine has an excellent effect on PCa cells. Sprycel is FDA approved already but used on Leukemia and is expensive (like $8,000 but you can buy it from Canada for like $2500). The patent on Sprycel will run out in 7-8 yrs., so maybe doubtful that clinical trials on using for PCa will happen. The good news is some companies are looking at this protocol and going overseas to either by pass or re-engineer the drug and get to market.
So two findings of using the combo with Cholorquine are already studied and known about. My onco doc says he read somewhere about Gleevec+Cholorquine also being useful. Now note that in the abstract I referrence and in the other using Sprycel...the drugs used separately do not have a huge effect on PCa, but when combined have real significance....shows how chemistry is key in things.
Possible future protocols on these:
Dasatinib (Sprycel)+ Cholorquine (being researched)
Sarcatinib + Cholorquine (in trials now)
Gleevec + Cholorquine (maybe use in off lable)
Maybe Sprycel + Cholorquine could be used by a doctor now in off label concept (both approved in other uses), cost is one variable and getting a doc to prescribe is another. The side effects possible are not that ridiculous as to someone trying these.
Don't be surprized to read future stuff about these concepts. Great that some researchers are looking way outside the box.
