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ADT 1, 2 and 3

On the website www.MyProstate.eu, under the heading: "Hormonal Therapy" they list ADT1, ADT2, and ADT3. Does anyone know what the difference is?

Re: ADT 1, 2 and 3

Sure, been there done that (lol) and maybe herein and idea for ADT4?

ADT1- usually refers to using single agent LHRH drugs, aka: Lupron, Zoladex, Trelstar, Precisis, Eligard, Degarelix type drugs

ADT2- usually refers to ADT1 above+ using: casodex, flutamides, eulexin, nilandron, biclutamides(casodex)

ADT3- usually refers to ADT1+ADT2 and now adding proscar, avodart, jalyn, terazosin type drugs.

ADT4- unheard off, but perhaps could be these four:
Lupron+casodex+proscar+DES (unofficial and perhaps worth a laugh-LOL)

Dr. Leibowitz is worthy reading on ADT3 combos, find his website to read if interested.

Re: ADT 1, 2 and 3

Thanks Bob.
You learrn something every day.

Re: ADT 1, 2 and 3 (A little more for good measure)

Reference found in Dr. Strum's book: A Primer on Prostate Cancer (2nd edition- the one with my picture on inside cover and Terry H. on back cover, etc.-LOL).
Page 135-136 gives more on this.

I supposed if a patient went unto casodex+proscar (only, not using Lupron), it would be called ADT2 in effect (because we are using 2 out of 3 classification types of drugs to fight PCa).

ADT1 could also be therefore, casodex only in mono-therapy, by the same reasonings.

I don't think anyone gets bent out of shape on these details. I have never seen anyone say I am on ADT2/3 meaning (casodex+proscar), but that might make classifing which drug(s) one is using simpler by the letters/number routine.

Just for kicks, another class of drugs in estrogenics exist and useful even on hrpca: estradiol patches (Vivelle, Mylan etc.) or gels; emcyt (estramustine); DES (man made compounded, patent ran out when Lupron introduced in the 1980's).

Other drugs working on the enzyme CYP17 to effect PCa:
Zytiga (expensive), TAK-700 (in clinical trials), Ketoconazole (cheap) These are consider 2nd line or later therapies for options in fighting.

Many other protocols exist visit www.hrpca.org (proven treatments for info on many including Provenge, Leukine, Revlimid, and more)

Re: ADT 1, 2 and 3 (A little more for good measure)

Hi Bob,

Dr. Strum, in a Life Extension article, talks about ADT4, the last element being Hytrin or Cozaar, which are usually prescribed for urinary problems, but which he thinks have cancer-killing properties. I remember taking Hytrin by itself and I didn't like the lousy feeling I had, but that was before I was diagnosed with cancer. I suppose, if prescribed now, I would have to tough it out. God knows what kind of reaction one would get to all all four of those drugs taken together.

Jack
USA

Re: ADT 1, 2 and 3

Just realised that I never thanked you all for your answers. THANKS! Another mystery solved.

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