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Re: low PSA, small cell prostate cancer? - increasing symptoms
You could have your pathology slides reviewed by Bostwick or Oppenheimer as they do test for variants and ploidy analysis of the PCa cells DNA (3-types of DNA) and atleast 24 variants of PCa have been found. There are a couple of them that are more aggressive and don't respond well to many drug protocols (some of the leading onco-docs use this information and have treated such patients...i.e. Myers, Strum, Scholz, Lam, Leibowitz, Sartor, and others). Sometimes in small cell the psa numbers are almost non-detectable levels or slight, but with symptoms and other things that oncologists might monitor. Dr. Strum recommends a number of additional testings in his book page 35..a couple of them are PAP and Prylinks-D tests and many other markers.
I have a continuing journey with some comparisons to yours (used flomax, had total urinary blockage PCa Dx-2002 Gleasons 7,8,9's and 2 sets like that, bpsa 46.6 all 12- cores 75-95% vol. with PCa). Did ADT3 with unique radiation protocol and later switched drugs to control this with lesser side effects and even better results were obtained...how long is my journey is yet to be determined. All cases are individualized to a large degree. You have alot more choices to try than just chemo or radiations...depends upon the docs you enlist...it varies plenty more than many would believe. Perhaps Terry will have some things to share on this, we all have alot of perspectives as patients dealing with this. Best going forward on this.
