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As to the differences between needle biopsy grades and post-surgical grades, there are many studies that demonstrate both undergrading and overgrading in the needle biopsy results. Usually these are about one third the same, one third under, one third over. And for some poor men, regrettably after surgery it is fond that the biopsy specimens were misread and thre was no tumour. Hence the recommendation to get a second opinion from Recognized Experts