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Re: how much tissue is examined in post op pathogy

Good question, Dan, and one that never occurred to me. I don't have much time now but will certainly try to chase this down. At my first attempt I found this link Guideline for optimization of surgical pathological quality performance for radical prostatectomy in prostate cancer management: surgical and pathological guidelines. and thought I'd hit the jackpot. But in fact it reminds me of the old joke about the accountant and the man in the balloon. It gives very precise information that is of now value in resolving your question!!

As to the differences between needle biopsy grades and post-surgical grades, there are many studies that demonstrate both undergrading and overgrading in the needle biopsy results. Usually these are about one third the same, one third under, one third over. And for some poor men, regrettably after surgery it is fond that the biopsy specimens were misread and thre was no tumour. Hence the recommendation to get a second opinion from Recognized Experts

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