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Re: Lingering effects of ADT?

At age 56 and after 2 years of Lupron, my testosterone level began to rise 6 months after cessation of the drug. By one year after cessation T levels were normal. The "no rules" applies again. I'm now 57 and still have some soft tissue damage from the radiation but judging by my other "symptoms", I am one of the lucky ones although the use of ED medication definitely improves the experience.

My understanding is that it takes at least 3 mos. after cessation for the pituitary gland to start stimulating the testes to produce testosterone and T level is totally unpredictible depending on the individual. - p (Alaska, USA)

Re: Lingering effects of ADT?

Many thanks for your comments. Overall, I am inclined to think that the good doctor meant well but, in this instance, has probably got it wrong.

My own experience, combined with the comments I hear and read from others, leads me to believe that testosterone levels will usually take some time to recover following the end of ADT. On the basis that lowered testosterone will, in most cases, have a limiting effect on tumour growth and probably on PSA readings, it seems likely that these two things may be affected for some time after the end of treatment.

Jeremy

Re: Lingering effects of ADT?

Hi Jeremy,
Hope you're well. My Casodex has led to very sore nipples. My surgeon said that even after I cease Casodex (some time after my HDR and EBRT) I can expect 3 months before the side effects go. Thereofre it's reasonable to assume, as you've done, that the lowering effect on PSA may also continue for up to 3 months.

But don't let that diminish your enjoyment of very low PSA for a man with a largely intact prostate!!

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