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Tim, my husband experienced extremely elevated liver function tests while on Casodex and a study drug. (AST and ALT 3 - 4 times upper normal and even higher). He discontinued both and liver function tests eventually returned to normal. He tried Casodex again a few months later and liver function tests started to rise immediately so again discontinued. He was being followed by Mayo Clinic at the time and they said this was a not uncommon side effect of Casodex. (He has taken low-dose Ketoconazole with no problem since August when PSA started to rise on Lupron).
