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I found this article Cancer’s Escape Routes very interesting. The research being done may well shed some light on why and how intermittent therapies may be better and also why some combinations of therapies may be helpful – and which they are.
These studies on the genetics of cells are fascinating, but I believe that the more that is discovered, the more they will find that we don’t know. The article concludes by summarising what is clear to many of us old hands, but less so, regrettably, to newbies and to many of the medical profession:
While there may be general principles that apply to cancer resistance, for now, treatment requires a tailored approach ……… With more thorough genetic sequencing, it’s become clear that there’s no single answer, even for a single patient. “We’re all looking for the common theme, so that we can find ways to overcome it,” Pao said. Unfortunately, “cancers are heterogeneous, not just across individuals, but within individuals.”